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. Author manuscript; available in PMC: 2013 Jan 1.
Published in final edited form as: Am J Transplant. 2011 Sep 22;12(1):69–80. doi: 10.1111/j.1600-6143.2011.03762.x

Figure 3. Dual costimulatory/integrin blockade prolongs graft survival.

Figure 3

(A) Survival curves of mOVA skin grafts in C57BL/6 recipients in which memory OT-I T cells were induced by LM-OVA infection. Recipients were either left untreated (n=15) or treated on POD#0,2,4 and 6 with costimulatory blockade alone (CTLA-4Ig + anti-CD154, n=24), anti-VLA-4 alone (n=5) or combined CoB + anti-VLA-4 (n=22). (B) Survival curves of mOVA skin grafts in C57BL/6 recipients in which memory OT-I T cells were induced by LM-OVA infection. Recipients were either left untreated or treated on POD#0,2,4 and 6 with costimulatory blockade alone (CTLA-4Ig + anti-CD154), anti-LFA-1 alone (n=15) or combined CoB + anti-LFA-1 (n=22). Combined results from four independent experiments are shown. All error bars represent the mean ± SEM.