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. 2012 May 31;40(18):e138. doi: 10.1093/nar/gks475

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© The Author(s) 2012. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 7. — The free energy penalty of tandem mismatches from experiment with target t₁: , where x′ and y′ are complementary to x and y, respectively. ab denoted above the x-axis are the fixed nucleotides in the target. mn is a tandem mismatch in the probe and the vertical position of these letters in the plot give the associated free energy penalty. Note the low free energy penalty for mismatches (encircled).

Inline graphic — The free energy penalty of tandem mismatches from experiment with target t₁: , where x′ and y′ are complementary to x and y, respectively. ab denoted above the x-axis are the fixed nucleotides in the target. mn is a tandem mismatch in the probe and the vertical position of these letters in the plot give the associated free energy penalty. Note the low free energy penalty for mismatches (encircled).