Table 1.
MiRNA that are differentially retained and exported in benign and malignant mammary epithelial cells (30)
| Release | Species | Benign |
Malignant |
||
|---|---|---|---|---|---|
| Cell | Microvesicle | Cell | Microvesicle | ||
| Neutral | miR-16 | +++ | ++ | +++ | ++ |
| miR-720 | ++ | ++ | +++ | +++ | |
| Selective | miR-451 | + | – | +/- | ++ |
| miR-1246 | + | – | + | ++ | |
Neutrally released miRNAs (n-miRNAs): the most consistently released miRNA of human mammary epithelial cells irrespective of malignancy is miR-16. MiR-720 is the most abundantly released miRNA of breast cancer cells tested. It is consistently released from both benign and malignant mammary epithelial cells. Selectively released miRNAs (s-miRNAs): cellular concentrations of miR-1246 and miR-451 are similar in benign and malignant cells; however, the release of these miRNAs is selective and excessive from malignant cells. + relative abundance in population by qRT–PCR and array; – not detectable in microvesicles; ± near threshold of detection.