Figure 4.

Features of high-grade melanomas. A, high-grade primary melanomas were significantly associated with increased mitotic rate, thickness, and ulceration. B, heat map showing that both molecular grades were evident in melanomas ≥2 mm. C and D, among melanomas greater than 2 mm, molecular grading was still predictive of survival. E, subset Kaplan–Meier analysis of the Winnepenninckx data set including melanomas ≥2 mm shows significant difference in patient survival. Breslow thickness: black, >4 mm; gray, 2 to 4 mm; ulcerated, dark gray; and no ulceration, light gray. TILs: brisk, light gray; nonbrisk, dark gray; absent, black; and absent data, white.