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. Author manuscript; available in PMC: 2013 Apr 15.
Published in final edited form as: J Immunol. 2012 Sep 12;189(8):4079–4087. doi: 10.4049/jimmunol.1201061

FIGURE 4.

FIGURE 4

Anti-IL-10R mAb treatment during BCG vaccination increases protection against Mtb in resistant C57BL/6 mice. C57BL/6 mice were treated with 1 mg anti-IL-10R mAb or isotype control mAb i.p. and the next day vaccinated with either 5 × 105 CFU BCG i.d. or PBS i.d. as control. Mice then received 0.35 mg anti-IL-10R mAb or isotype control mAb i.p. weekly following vaccination for 6-weeks. Two weeks after the final weekly mAb administration, mice were challenged by Mtb aerosol, and bacterial load per lungs and per spleen was determined at 28-days and 63-days post challenge. Data shown depict the mean ± SEM from one experiment (n = 5 per group). ***p < 0.001 by one-way ANOVA; ++p < 0.01 by unpaired Student’s t-test.