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. Author manuscript; available in PMC: 2013 Apr 15.
Published in final edited form as: J Immunol. 2012 Sep 12;189(8):4079–4087. doi: 10.4049/jimmunol.1201061

FIGURE 7.

FIGURE 7

The enhanced protection in anti-IL-10R mAb-treated/BCG vaccinated CBA/J mice is accompanied by enhanced PPD-specific cytokine responses in the lung during Mtb challenge. CBA/J mice were vaccinated with either concomitant anti-IL-10R mAb or isotype control mAb, and Mtb-challenged as previously described for Fig. 6. Lung cells were isolated at 63- and 112-days post challenge and were restimulated with PPD and anti-CD28 as described in Materials and Methods. IFN-γ, TNF-α, IL-6, and IL-17A were measured in the supernatants of these restimulations by ELISA. Data shown are from one of two independent experiments (n = 5 per group) and depict the mean ± SEM. ns = not significant. *p < 0.05, **p < 0.01, ***p < 0.001 by one-way ANOVA.