Table I.
Patient characteristics (n = 163)
| n | % | |
|---|---|---|
| Male | 57 | 35 |
| Female | 106 | 65 |
| Mean age at NIH operation (yrs) ±SEM | 51.5 ± 1.1 | |
| Range of age at NIH operation (yrs) | 16–78 | |
| History of neck radiation | 13 | 8 |
| Presentation | ||
| Asymptomatic patients | 27 | 17 |
| Patients with ≥1 symptom or sign | 136 | 83 |
| Symptoms and signs | ||
| Fatigue | 75 | 46 |
| Nephrolithiasis | 74 | 45 |
| Neuropsychiatric | 51 | 31 |
| Bone pain | 31 | 19 |
| Gastrointestinal complaints | 28 | 17 |
| Muscle weakness | 14 | 9 |
| Nocturnal polyuria | 10 | 6 |
| Fractures | 6 | 3.7 |
| Bone densitometry (at NIH; data available for 139 pts) | ||
| Osteopenia (2.5 < worst T score < 2.0) | 24 | 17 |
| Osteoporosis (worst T score ≤ 2.5) | 74 | 53 |
| Neither | 41 | 30 |
| Mean T score ±SEM | −2.6 ± 0.1 | |
| Range of T score | −6.3–2.7 | |
| Biochemical evaluation assay | NIH normal range* | Mean pre-operative (± SEM) | Mean discharge (± SEM) | Mean -%Δ (± SEM) |
|---|---|---|---|---|
| Venous ionized calcium (mmol/L) | 1.22–1.38 | 1.54 (0.01) | 1.23 (0.01) | 19.9 (0.7) |
| Intact parathyroid hormone (pg/mL) | 16–87 | 151.9 (12.1) | 23.7 (2.1) | 77.4 (2.4) |
*
Current NIH normal range; normal ranges have varied slightly during the time period of this study.