Table 2.
Matched odds ratios and 95% confidence intervals of prostate cancer recurrence for candidate single nucleotide polymorphisms (SNPs) in genes involved in immune response, production of reactive oxygen species (ROS), detoxification of ROS, and repair of oxidative DNA damage, men who underwent prostatectomy at John Hopkins Hospital, 1993–2001
| Number of minor alleles | At least 1 minor allele |
||||||||
|---|---|---|---|---|---|---|---|---|---|
| None | 1 copy | 2 copies | |||||||
| Gene | dbSNP | Cases/ controls (genotype) |
Cases/ controls (genotype) |
OR (95% CI) |
Cases/ controls (genotype) |
OR (95% CI) |
Pb | Cases/ controls (genotype) |
OR (95% CI) |
| IL10 | |||||||||
| rs1800872 | 236/253 (CC) |
171/168 (AC) |
1.09 (0.83–1.44) |
35/21 (AA) |
1.76 (1.00–3.10) |
0.09 | 206/189 (A-carrier) |
1.17 (0.90–1.52) |
|
| rs1800896 | 146/112 (AA) |
212/242 (AG) |
0.66 (0.48–0.91) |
100/104 (GG) |
0.74 (0.51–1.06) |
0.08 | 312/346 (G-carrier) |
0.69 (0.51–0.92) |
|
| CRP | |||||||||
| rs1205 | 221/186 (GG) |
171/219 (AG) |
0.65 (0.49–0.86) |
51/38 (AA) |
1.21 (0.76–1.94) |
0.27 | 222/257 (A-carrier) |
0.74 (0.57–0.96) |
|
| rs1800947 | 418/385 (GG) |
40/75 (CG) |
0.50 (0.33–0.75) |
2/0 (CC) |
N/A | 0.004 | 42/75 (C-carrier) |
0.53 (0.36–0.79) |
|
| GSTP1 | |||||||||
| rs1695 | 204/240 (AA) |
196/165 (AG) |
1.40 (1.06–1.86) |
46/61 (GG) |
1.35 (0.84–2.16) |
0.004 | 242/226 (G-carrier) |
1.39 (1.06–1.82) |
|
| hOGG1 | |||||||||
| rs293795 | 312/320 (AA) |
134/126 (AG) |
1.09 (0.82–1.45) |
16/16 (GG) |
1.03 (0.50–2.11) |
0.63 | 150/142 (G-carrier) |
1.08 (0.82–1.43) |
|
| IL1B | |||||||||
| rs1143627 | 209/174 (TT) |
188/196 (CT) |
0.80 (0.60–1.06) |
53/80 (CC) |
0.54 (0.36–0.81) |
0.003 | 241/276 (C-carrier) |
0.73 (0.56–0.95) |
|
| IL6 | |||||||||
| rs1800795a | 211/206 (GG) |
200/191 (CG) |
1.02 (0.78–1.35) |
54/68 (CC) |
0.77 (0.51–1.16) |
0.36 | 254/259 (C-carrier) |
0.96 (0.74–1.24) |
|
| IL8 | |||||||||
| rs4073 | 121/133 (TT) |
218/207 (AT) |
1.14 (0.85–1.54) |
107/106 (AA) |
1.10 (0.76–1.59) |
0.55 | 325/313 (A-carrier) |
1.13 (0.85–1.50) |
|
| MPO | |||||||||
| rs12452417 | 334/323 (CC) |
96/99 (CT) |
0.95 (0.69–1.31) |
15/23 (TT) |
0.65 (0.34–1.24) |
0.26 | 211/222 (T-carrier) |
0.89 (0.66–1.19) |
|
| rs12944679 | 259/250 (GG) |
135/138 (AG) |
0.95 (0.71–1.27) |
41/47 (AA) |
0.85 (0.54–1.33) |
0.46 | 176/185 (A-carrier) |
0.92 (0.71–1.20) |
|
| rs12451466 | 334/317 (CC) |
94/102 (CT) |
0.88 (0.64–1.22) |
14/23 (TT) |
0.60 (0.31–1.17) |
0.12 | 108/125 (T-carrier) |
0.82 (0.61–1.11) |
|
| NOS3 | |||||||||
| rs1799983a | 230/235 (GG) |
159/173 (GT) |
0.95 (0.72–1.26) |
44/25 (TT) |
1.75 (1.04–2.93) |
0.20 | 203/198 (T-carrier) |
1.05 (0.80–1.37) |
|
| SOD1 | |||||||||
| rs2070424a | 369/370 (AA) |
69/66 (AG) |
1.06 (0.72–1.56) |
5/7 (GG) |
0.72 (0.23–2.26) |
0.93 | 74/73 (G-carrier) |
1.02 (0.70–1.47) |
|
| SOD2 | |||||||||
| rs4880 | 131/117 (TT) |
233/236 (CT) |
0.89 (0.66–1.20) |
108/119 (CC) |
0.81 (0.56–1.16) |
0.24 | 341/355 (C-carrier) |
0.86 (0.65–1.15) |
|
| SOD3 | |||||||||
| rs699473 | 194/178 (TT) |
206/223 (CT) |
0.85 (0.64–1.12) |
71/70 (CC) |
0.92 (0.63–1.36) |
0.48 | 277/293 (C-carrier) |
0.86 (0.66–1.13) |
|
| rs1799895 | 452/456 (CC) |
−/− | N/A | 15/11 (GG) |
1.36 (0.63–2.97) |
0.43 | 15/11 (G-carrier) |
1.36 (0.63–2.97) |
|
| rs2855262 | 182/164 (CC) |
193/213 (CT) |
0.80 (0.59–1.08) |
72/70 (TT) |
0.91 (0.60–1.39) |
0.41 | 265/283 (T-carrier) |
0.82 (0.62–1.10) |
|
| TLR4 | |||||||||
| rs4986790 | 393/387 (AA) |
55/62 (AG) |
0.88 (0.60–1.30) |
3/2 (GG) |
1.39 (0.23–8.46) |
0.64 | 58/64 (G-carrier) |
0.89 (0.60–1.31) |
|
| TNF | |||||||||
| rs1800629 | 341/336 (GG) |
113/126 (AG) |
0.88 (0.65–1.20) |
14/6 (AA) |
2.25 (0.86–5.88) |
0.84 | 127/132 (A-carrier) |
0.95 (0.71–1.27) |
|
a
Both a candidate and Tagging SNP
b
For the additive model