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. Author manuscript; available in PMC: 2013 Nov 1.
Published in final edited form as: Drug Alcohol Depend. 2012 Jun 8;126(1-2):268–271. doi: 10.1016/j.drugalcdep.2012.05.006

Figure 1.

Figure 1

Mean (± SE) relative pupil diameter for 10 neonates exposed to opioids in utero who required pharmacological treatment for NAS postnatally. Neonates were stabilized on methadone (0.4–0.5 mg every 12 hours) and relative pupil diameter measurements were calculated from pictures taken just prior to dosing (Pre) and 0–1, 2–4, 5–7, and 8–10 hours after dosing. * Indicates the 0–1 time point is significantly different from the Pre time point (p <.001). ** Indicates a significant linear time trend across the 4 post-dosing time points (p <.001).