Table 2.

Mean DAS-28 in overall and treatment group among ‘smokers’ & ‘non- smokers’ (n = 412).

Group	Baseline DAS-28		Mean DAS-28 weeks 48-102		p- value*
	‘Non- smokers’	‘Smokers’	‘Non- smokers’	‘Smokers’
Overall group	5.8 (1.0)	5.8 (1.1)	3.17 (1.3)	3.14 (1.3)	0.881
Active Etanercept + MTX	5.9 (1.1)	5.7 (1.0)	3.01 (1.3)	3.07 (1.2)	0.797
Active Triple Therapy	5.7 (1.0)	5.7 (1.3)	3.24 (1.3)	3.15 (1.9)	0.809
Step-Up Etanercept	5.6 (1.1)	6.1 (1.1)	3.31 (1.3)	3.20 (1.4)	0.688
Step-Up Triple therapy	5.8 (0.9)	5.9 (1.0)	3.07 (1.4)	3.23 (1.1)	0.667

^*P-value represents difference (smokers vs. non-smokers) in mean DAS-28 at weeks 48 to 102 after adjusting for baseline value; Number of participants by treatment arm = Active Etanercept + MTX (n = 143); Active Triple Therapy (n = 69), Step-Up Etanercept (n = 136); Step-Up Triple Therapy (n = 64).