Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Mechanism of Sirt1activation by RSV. The metabolic effects of RSV can be accounted for competitive inhibition of cAMP-degrading phosphodiesterases and the elevation of cytosolic calcium via the cAMP effector protein Epac1. This pathway activates the calcium/calmodulin-dependent protein kinase II which phosphorylates AMPK, which in turn increases of NAD+ levels, thus leading ultimately to SIRT1 activation.
