Table 4.
Hazard ratios for breast cancer mortality stratified by stage and major breast cancer subtypes (N=934)
| Alive or Died of Other Causes N |
Died of Breast Cancer N |
Univariate HR | 95% CI | Adjusted HRa | 95% CI | |
|---|---|---|---|---|---|---|
| All Stages | ||||||
| Luminal A | 490 | 128 | 1.00 | 1.00 | ||
| Luminal B | 25 | 15 | 2.01 | 1.18–3.42 | 1.96 | 1.08–3.54 |
| Basal Like | 157 | 52 | 1.30 | 0.94–1.79 | 1.20 | 0.80–1.82 |
| HER2-enriched | 41 | 26 | 2.39 | 1.57–3.64 | 2.56 | 1.53–4.29 |
| Stage 1 | ||||||
| Luminal A | 316 | 30 | 1.00 | 1.00 | ||
| Luminal B | 12 | 3 | 2.38 | 0.73–7.81 | 7.39 | 1.72–31.77 |
| Basal Like | 72 | 10 | 1.37 | 0.67–2.79 | 1.61 | 0.54–4.81 |
| HER2-enriched | 15 | 4 | 2.90 | 1.02–8.26 | 6.62 | 1.78–24.57 |
| Stage 2 | ||||||
| Luminal A | 156 | 65 | 1.00 | 1.00 | ||
| Luminal B | 12 | 9 | 1.84 | 0.92–3.69 | 2.23 | 1.01–4.96 |
| Basal Like | 78 | 29 | 1.06 | 0.68–1.64 | 1.22 | 0.71–2.11 |
| HER2-enriched | 25 | 12 | 1.26 | 0.68–2.33 | 1.85 | 0.89–3.85 |
| Stage 3–4 | ||||||
| Luminal A | 18 | 33 | 1.00 | 1.00 | ||
| Luminal B | 1 | 3 | 1.37 | 0.42–4.48 | 0.76 | 0.17–3.39 |
| Basal Like | 7 | 13 | 1.49 | 0.78–2.84 | 0.94 | 0.31–2.86 |
| HER2-enriched | 1 | 10 | 3.47 | 1.68–7.19 | 1.11 | 0.25–4.89 |
a
Hazard ratios are adjusted for age at diagnosis, years of first breast cancer diagnosis, menopausal status, lymph node status, stage at diagnosis, and treatment regimens.
Note: 7 dichotomous variables were created to represent eight breast cancer treatment categories:
1) surgery+radiation+chemotherapy+tamoxifen; 2) surgery+radiation+chemotherapy; 3) surgery+radiation+tamoxifen; 4) surgery+ chemotherapy+tamoxifen; 5) surgery+radiation; 6) surgery+chemotherapy; 7) surgery+ tamoxifen; 8) surgery only.