Table 1.

Risk reclassification table comparing one-year risk of all-cause mortality or cardiac transplantation from Cox regression models with NT-proBNP and SHFM, but with and without ST2. Cases and controls estimated from Kaplan-Meier risk at one year; Cases = All × Observed risk / 100; Controls = All × (1 – Observed risk / 100).

	Model with ST2					Reclassified, %
Model without ST2	0% to <10%	10% to <20%	20% to <50%	50% to 100%	Total, n (%)	Lower	Higher	Total
0% to <10%
All, n (%)	613 (97)	20 (3)	0 (0)	0 (0)	633 (56)	–	3	3
Cases, n (%)	19.2 (85)	3.0 (13)	0 (0)	0 (0)	22.2 (15)	–	13	13
Controls, n (%)	593.8 (95)	17.0 (3)	0 (0)	0 (0)	610.8 (54)	–	3	3
Observed risk, %	3.1	15.0			3.5
10% to <20%
All, n (%)	49 (19)	183 (71)	27 (10)	0 (0)	259 (23)	19	10	29
Cases, n (%)	0.0 (0)	23.1 (77)	6.2 (21)	0 (0)	29.3 (20)	0	21	21
Controls, n (%)	49.0 (21)	159.9 (68)	20.8 (9)	0 (0)	229.7 (24)	21	9	30
Observed risk, %	0.0	12.6	22.8		11.3
20% to <50%
All, n (%)	3 (2)	34 (17)	143 (73)	17 (9)	197 (18)	19	9	28
Cases, n (%)	1.0 (2)	10.4 (21)	52.2 (80)	9.0 (7)	72.4 (49)	23	7	30
Controls, n (%)	2.0 (2)	23.6 (21)	90.8 (80)	8.0 (7)	124.6 (13)	23	7	30
Observed risk, %	33.3	30.7	36.5	52.9	36.8
50% to 100%
All, n (%)	0 (0)	0 (0)	5 (14)	31 (86)	36 (3)	14	–	14
Cases, n (%)	0 (0)	0 (0)	2.0 (8)	22.0 (93)	24.3 (16)	8	–	8
Controls, n (%)	0 (0)	0 (0)	3.0 (26)	9.0 (79)	11.7(1)	26	–	26
Observed risk, %			40.0	71.0	67.4
Total
All, n (%)	665 (59)	237 (21)	175 (16)	48 (4)	1125 (100)	–	–	–
Cases, n (%)	20.3 (14)	36.4 (24)	60.5 (41)	31.0 (21)	148.6 (100)	–	–	–
Controls, n (%)	644.7 (66)	200.6 (21)	114.5 (12)	17.0 (2)	976.4 (100)	–	–	–
Observed risk, %	3.1	15.4	34.5	64.6	13.2