Table 5-B.
Fatty acid concentrations (nmol/g) in brain glycerophospholipids of control and HIV-1 Tg rats
EtnGpl
|
ChoGpl
|
PtdIns
|
PtdSer
|
|||||
---|---|---|---|---|---|---|---|---|
Control | HIV | Control | HIV | Control | HIV | Control | HIV | |
14:0 | 79 ± 25 | 72 ± 2 | 15 ± 12 | 11 ± 7 | ||||
16:0 | 2147 ± 533 | 2551 ± 106 | 18365 ± 715 | 18615 ± 812 | 513 ± 56 | 541 ± 42 | 439 ± 53 | 477 ± 58 |
18:0 | 6786 ± 319 | 6788 ± 310 | 6161 ± 271 | 6176 ± 175 | 1611 ± 124 | 1653 ± 64 | 6074 ± 399 | 6161 ± 403 |
20:0 | 62 ± 12 | 70 ± 13 | 12 ± 2 | 14 ± 1* | 71 ± 18 | 69 ± 11 | ||
22:0 | 15 ± 4 | 15 ± 4 | 100 ± 16 | 102 ± 12 | ||||
24:0 | 11 ± 2 | 19 ± 5* | 43 ± 7 | 42 ± 8 | ||||
16:1n-7 | 174 ± 10 | 174 ± 14 | 221 ± 21 | 213 ± 9 | 11 ± 3 | 10 ± 1 | 22 ± 17 | 14 ± 2 |
18:1n-9 | 6652 ± 612 | 6936 ± 696 | 8869 ± 414 | 8888 ± 337 | 628 ± 76 | 643 ± 51 | 2843 ± 227 | 2915 ± 281 |
18:1n-7 | 1743 ± 245 | 1946 ± 220 | 3609 ± 175 | 3768 ± 154 | 548 ± 792 | 230 ± 31 | 517 ± 148 | 542 ± 79 |
20:1n-9 | 342 ± 86 | 407 ± 97 | 284 ± 33 | 348 ± 100 | 28 ± 5 | 26 ± 10 | 77 ± 25 | 95 ± 25 |
22:1n-9 | 51 ± 15 | 40 ± 25 | 108 ± 14 | 133 ± 19* | ||||
24:1n-9 | 35 ± 1 | 36 ± 7 | ||||||
18:2n-6 | 286 ± 26 | 340 ± 40* | 334 ± 31 | 468 ± 68*** | 35 ± 3 | 49 ± 7** | 34 ± 11 | 44 ± 7 |
18:3n-6 | 29 ± 7 | 31 ± 8 | 22 ± 9 | 19 ± 4 | ||||
20:2n-6 | 53 ± 5 | 64 ± 17 | 21 ± 11 | 20 ± 6 | ||||
20:4n-6 | 4881 ± 268 | 4856 ± 224 | 2314 ± 157 | 2230 ± 209 | 1353 ± 90 | 1385 ± 68 | 498 ± 41 | 496 ± 39 |
22:4n-6 | 1912 ± 139 | 1857 ± 93 | 316 ± 22 | 308 ± 11 | 56 ± 8 | 58 ± 3 | 472 ± 42 | 452 ± 24 |
22:5n-6 | 161 ± 16 | 157 ± 19 | 109 ± 14 | 104 ± 11 | ||||
18:3n-3 | 1260 ± 225 | 1476 ± 269 | 479 ± 64 | 539 ± 73 | 82 ± 17 | 88 ± 17 | 353 ± 70 | 416 ± 93 |
20:3n-3 | 132 ± 13 | 129 ± 13 | 101 ± 12 | 100 ± 17 | 11 ± 6 | 12 ± 2 | 40 ± 6 | 39 ± 4 |
20:5n-3 | 42 ± 12 | 43 ± 8 | ||||||
22:5n-3 | 64 ± 21 | 82 ± 24 | 23 ± 7 | 30 ± 4 | ||||
22:6n-3 | 5628 ± 252 | 5632 ± 255 | 1389 ± 32 | 1373 ± 61 | 120 ± 17 | 111 ± 17 | 2399 ± 166 | 2370 ± 191 |
Total SFAs | 8996 ± 627 | 9411 ± 400 | 24605 ± 891 | 24863 ± 931 | 2159 ± 182 | 2234 ± 98 | 6740 ± 428 | 6860 ± 450 |
Total MUFAs | 8911 ± 918 | 9464 ± 931 | 13039 ± 596 | 13285 ± 478 | 1213 ± 786 | 905 ± 89 | 3459 ± 386 | 3564 ± 305 |
Total n-6 PUFAs | 7313 ± 404 | 7295 ± 304 | 2964 ± 184 | 3006 ± 230 | 1444 ± 97 | 1492 ± 68 | 1153 ± 91 | 1129 ± 72 |
Total n-3 PUFAs | 7084 ± 371 | 7307 ± 305 | 1971 ± 81 | 2011 ± 107 | 213 ± 28 | 207 ± 37 | 2816 ± 171 | 2847 ± 166 |
Total fatty acids | 32303 ± 1975 | 33477 ± 1513 | 42606 ± 1514 | 43179 ± 1354 | 5086 ± 843 | 4880 ± 258 | 14343 ± 1013 | 14606 ± 915 |
Ratio of n-6/n-3 | 1.0 ± 0.02 | 1.0 ± 0.05 | 1.5 ± 0.1 | 1.5 ± 0.2 | 6.8 ± 0.5 | 7.4 ± 1.2 | 0.4 ± 0.03 | 0.4 ± 0.01 |
Ratio of AA/DHA | 0.9 ± 0.03 | 0.9 ± 0.03 | 1.7 ± 0.1 | 1.6 ± 0.2 | 11.4 ± 1.4 | 12.7 ± 1.9 | 0.2 ± 0.02 | 0.2 ± 0.01 |
Values are mean ± SD of n=7 per group.
SFAs, saturated fatty acids; MUFAs, monounsaturated fatty acids; PUFAs, polyunsaturated fatty acids; ND, not detected. P<0.05,
P< 0.01,
P<0.001 by unpaired t-test.