Table 1.
*I/IC50 [3H] nicotine | I/IC50 125I-labeled α-bungarotoxin | Male |
Female |
|||
---|---|---|---|---|---|---|
LD50 | LD90 | LD50 | LD90 | |||
Nicotine | 100/(2 ± 0.1) × 10−7 | 100/(1 ± 0.3) × 10−5 | 31 ± 4 | 43 ± 6 | 37 ± 6 | 51 ± 9 |
Cotinine | 100/(2 ± 0.2) × 10−3 | 100/(1 ± 0.2) × 10−3 | 2 ± 0.1 | 4 ± 0.1 | 3 ± 0.1 | 4 ± 0.1 |
*I/IC50, percentage maximum inhibition/concentration of drug that inhibits 50% radioligand binding (in M). Values of IC50, mean ± SD. LD, lethal dose with nicotine attributed 100% toxicity (Riah et al., 1999).