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. 2012 Oct 10;2:125. doi: 10.3389/fcimb.2012.00125

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Copyright © 2012 Flores-Kim and Darwin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.

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Activation of the Psp ESR and relief of YscC-induced stress in Y. enterocolitica. In the absence of Ysc-Yop T3SS production, PspA binds to the transcription factor PspF in the cytoplasm and inhibits it. When the Ysc-Yop apparatus is produced some of its secretin component (YscC) mislocalizes into the cytoplasmic membrane. This event is sensed by the PspBC proteins, which then switch into their active state and sequester PspA away from PspF, allowing it to activate the pspA operon promoter. Elevated levels of PspBC then stop mislocalized YscC from causing lethal cytoplasmic membrane permeability by an unknown mechanism. OM, outer membrane; IM, inner (cytoplasmic) membrane.