Table 1.
Summary of outcome measures and time points of assessment
| Baseline | Weekly in ICU | ICU discharge | Acute hospital discharge** | |
|---|---|---|---|---|
| Muscle composition and thickness measures | ||||
| Bioimpedance spectroscopy | ✓ | ✓ | ✓ | ✓ |
| Quadriceps ultrasonography | ✓ | ✓ | ✓ | ✓ |
| Strength measures | ||||
| MRC score | ✓ | ✓ | ✓ | |
| HHD grip and quadriceps | ✓ | ✓ | ✓ | ✓ |
| Physical function measures | ||||
| PFIT | ✓ | ✓ | ✓ | |
| FSS-ICU score | ✓ | ✓ | ✓ | |
| 6-MWT | ✓ | |||
| Biomarker measures | ||||
| Muscle biopsy | ✓ | ✓ | ||
| Urine analyses | ✓ | ✓ | ✓ | |
| Blood analyses | ✓ | ✓ | ✓ | |
FSS-ICU, functional status score in intensive care; HHD, hand-held dynamometry; MRC, medical research council; PFIT, physical function in intensive care test; 6-MWT, six minute walk test.
** If patient is unable to walk >10 m unaided or with usual gait aid, ICU discharge measures will be completed at this time-point.