Table 1.

Estimated mean (LSmean±SE) average changes in urges-to-smoke scores and corresponding comparisons between treatments (estimated treatment difference (97.5% CI) and Bonferroni-adjusted p value) at 1, 3, 5 and 10 min postadministration by treatment

	Average score changes from baseline (mm)*
Time	Nicotine mouth spray 2 mg	Nicotine lozenge 2 mg	Nicotine lozenge 4 mg	Spray vs 2 mg lozenge	Spray vs 4 mg lozenge
1 min	−11.91±0.72	−3.97±0.72	−4.80±0.72	−7.9 (−9.8, −6.1) p<0.001	−7.1 (−9.0, −5.2) p<0.001
3 min	−23.65±1.21	−10.14±1.20	−11.62±1.20	−13.5 (−16.4, −10.6) p<0.001	−12.0 (−14.9, −9.1) p<0.001
5 min	−29.19±1.32	−15.27±1.31	−17.03±1.31	−13.9 (−16.9, −10.9) p<0.001	−12.2 (−15.2, −9.2) p<0.001
10 min	−35.78±1.45	−23.34±1.44	−25.46±1.44	−12.4 (−15.5, −9.4) p<0.001	−10.3 (−13.4, −7.3) p<0.001

*AUC_{n min}/n—baseline urges-to-smoke score (mm).

AUC, area under the urges-to-smoke-vs.-time curve