Table 1. Details of TACC3/ch-TOG/clathrin complex members.
| Membe r |
Compositio n |
Humans | Homologues | Notes | Referenc e |
|---|---|---|---|---|---|
| TACC3 | 2 × 90 kDa (monomer runs at 150 kDa by SDS PAGE). |
TACC3/ERIC 1 (838) |
Tacc3/AINT (mm, 630), TACC3/Maskin (xl, 931), dTACC (dm, 1226), C7G031 (dd, 616), TAC-1/2P40 (ce, 260), ALP7/Mia1 (sp, 474). |
TACC1 and TACC2 expressed in mammals. No clear homologue in plants or S. cerevisiae. Best sc candidates are SLK19 (sc, 821) with weak homology or Spc72 (sc, 622) due to interaction with STU2. TACC domain is best conserved and N- terminal region is variable. |
(Still et al., 2004) |
| Ch- TOG |
1 × 225 kDa | CKAP5/ch- TOG (2032) |
Ckap5 (mm, 2032), XMAP215 (xl, 2065), Msps (dm, 2050), MOR1 (at, 1978), CP224 (dd, 2013), Zyg-9 (ce, 1415), Alp14/Dis1 (sp, 809), STU2 (sc, 888). |
Higher eukaryotes have 5 TOG domains. Zyg-9 has 3 TOG domains and yeast homologues have 2 TOG domains. |
(Al-Bassam and Chang, 2011) |
| Clathrin | 3 × (190 + 27 kDa) |
CLTC/CHC (1675) CLTCL1/CHC 22 (1640) |
Cltc(mm, 1675), cltc (xl, 1675), Chc (dm, 1678), AT3G11130 (at, 1705), chcA (dd, 1694), chc-1 (ce, 1681), chc1 (sp, 1666), CHC1 (sc, 1653). |
Domain organisation of CHC is completely conserved down to yeast. Homologues of CHC22 are present in mammals (pseudogene in mice), birds, amphibians and fish. |
(Wakeha m et al., 2005) |
| CLTA/LCa (248) CLTB/LCb (229) |
Clta (mm, 216), Clta (xl, 203), clc(dd, 194), F4J5M9 (at, 258), Clc (dm, 219), clic-1 (ce, 226), clc1 (sp, 229), CLC1 (sc, 233) |
Homologues of both LCa and LCb in mammals, birds, amphibians and fish. Only LCa homologues are shown here. Single light chains in flies, worms, slime mold and fungi. Three light chain genes in Arabidopsis. |
(Wakeha m et al., 2005) |
Numbers in parentheses refer to the number of amino acids of the longest isoform. Abbreviations: mm, mouse; xl, frog; dm, fruitfly; at, plant; dd, slime mould; ce, nematode; sp, fission yeast; sc, budding yeast.