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. Author manuscript; available in PMC: 2013 Mar 1.
Published in final edited form as: Gynecol Oncol. 2011 Nov 22;124(3):589–597. doi: 10.1016/j.ygyno.2011.11.019

Figure 5. RhoB induction in response to combinatorial treatment in HOVTAX2.

Figure 5

A. Quantitative PCR (QPCR) of RhoB mRNA levels after treatment with 50 nM sunitinib (Sut) and 10 nM ixabepilone (Ixa) show that in combination, RhoB levels increase ~6-fold in naïve cells and ~4-fold in paclitaxel resistant cells. Data is plotted as fold change as compared to DMSO control ± S.D. *p<0.05 B. Western blot analysis of RhoB confirms RhoB is only induced when sunitinib and ixabepilone are used in combination. β-actin is a loading control