Figure 2.
Schematic of the QR-Tf-saquinavir bioconjugate and the transversing potential of the QR-Tf-saquinavir nanoformulation across an in vitro BBB.
Copyright © 2010, Bentham Science.
Reproduced with permission from Mahajan SD, Roy I, Xu G, et al. Enhancing the delivery of anti retroviral drug “Saquinavir” across the blood brain barrier using nanoparticles. Curr HIV Res. 2010;8(5):396–404.75
Abbreviations: BBB, blood–brain barrier; QR, quantum rods Tf, transferrin; PET, polyethylene terephthalate; CNS, central nervous system; PBMC, peripheral blood mononuclear cells; NHA, normal human astrocytes; Baso, basophil; HIV-1, human immunodeficiency virus-1; BMVEC, brain microvascular endothelial cells; TEER, transendothelial electric resistance; LTR, long terminal repeat; PCR, polymerase chain reaction, ELISA, enzyme-linked immunosorbent assay.