Table II.

Body Weight, Blood Pressure, Plasma Na⁺ and K⁺, Urine Volume, GFR, and Na⁺ and K⁺ Excretion in +/sv and sv/sv Mice

	Genotype
Physiological Parameters	+/sv	sv/sv
BW (g)	34.8 (5.4)	24.3 (2.8)a
BP (mm Hg)	100.8 (7.7)	116.7 (10.5)b
PNa (mM)	153.34 (5.07)	154.25 (7.27)
PK (mM)	4.29 (0.61)	3.96 (0.40)
UV (µl/min)	0.88 (0.40)	1.19 (0.41)
GFR (ml/min/100g BW)	0.51 (0.25)	0.73 (0.25)
ENa (µEq/min/100g BW)	0.22 (0.17)	0.63 (0.49)
EK (µEq/min/100g BW)	0.46 (0.20)	0.77 (0.43)
FENa (%)	0.31 (0.21)	0.56 (0.32)
FEK (%)	24.44 (13.78)	28.37 (15.13)

Mean values and SD (in parentheses) of physiological parameters measured in renal clearance studies of mice aged 19–21 months (n = 6 per genotype).

^aP<0.01.

^bP<0.05.