Figure 4.

Simulated application of another ICpeptide in a model of SCA1/2/3 can restore normal calcium release. Hyperactive calcium release in the presence of mutant Ataxin can be overcome by application of IC-G2736X, which resembles the polyglutamine binding domain in the C-terminal of IP3R1, and was developed by Tang et al. [52]. Note that the dashed light grey line (representing restoration of normal calcium release by application of ICpeptide in the context of a mutant Ataxin model) directly superimposes on the solid black line (which represents wild type).