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. Author manuscript; available in PMC: 2012 Oct 10.
Published in final edited form as: Nat Immunol. 2011 Nov 20;13(2):144–151. doi: 10.1038/ni.2187

Figure 1.

Figure 1

AHR is essential for IL-22-production in the intestinal LP and resistance to C. rodentium infection. (a) Cells were isolated from siLP, PP, and MLN of AHR-/- and WT mice. Identical numbers of cells were stimulated with IL-23. IL-22 released in culture supernatant was measured by ELISA. One experiment representative of two is shown. (b) Survival rates after C. rodentium infection. AHR-/- mice and WT mice were orally inoculated with C. rodentium. Data are from 2 independent experiments (n=6). (c,d) Histological analysis from H&E staining of representative colons from WT (c) and AHR-/- (d) mice 6 days post inoculation reveals increased mucosal hyperplasia and epithelial erosion in AHR-/- colons. Scale bars 25μm. (e) Histological scores for colons from WT and AHR-/- mice from (c and d). (f) C. rodentium titers in the spleen 6 days after inoculation.