Fig. 3.

Coronary artery segments were preconstricted with endothelin to assess vasodilatory responses to 10⁻⁶ mol/l arachidonic acid. Results were compared between endothelial intact arteries in buffer alone (PSS), rubbed arteries with endothelial inactivation, and arteries pretreated with either indomethacin (10⁻⁵ mol/l) or the selective COX2 antagonist NS398 (10⁻⁵ mol/l). Responses were assessed in Dex-exposed lambs (solid symbols, N = 7) and control lambs (open symbols, N = 7). *P < 0.05 vs. control, ‡P < 0.01 vs. PSS alone.