Table 5. Summary OR (95%CI) and I2 for G-403A polymorphism and coronary artery disease under AA vs GG and GA vs GG contrasts.
| Subgroup | AA vs GG | GA vs GG | ||
| N§ | OR (95% CI) I2(%) | N | OR (95% CI) I2(%) | |
| Source of controls | ||||
| Population based | 5 | 1.208 (0.631–2.314) 71.3 | 5 | 0.949 (0.749–1.201) 54.4 |
| Hospital based | 2 | 1.084 (0.671–1.754) 8.4 | 2 | 1.074 (0.655–1.759) 72.9 |
| Ethnicity | ||||
| Caucasians | 5 | 1.595 (0.918–2.772) 48.8 | 5 | 1.129 (0.948–1.344) 27.8 |
| Asians | 2 | 0.672 (0.480–0.940) 0 | 2 | 0.737 (0.568–0.955) 10.2 |
| Cases definition | ||||
| CA | 5 | 1.088 (0.661–1.792) 59.1 | 4 | 0.987 (0.687–1.418) 81.7 |
| Non-CA | 3 | 1.442 (0.464–4.480) 75.4 | 3 | 1.104 (0.713–1.710) 0 |
| HWE violation | ||||
| Yes | 2 | 2.695 (0.232–31.370) 82.0 | 2 | 1.279 (1.054–1.552) 0 |
| No | 5 | 1.054 (0.643–1.727) 57.9 | 5 | 0.900 (0.714–1.136) 51.9 |
| Genotyping method | ||||
| RFLP | 4 | 1.879 (0.844–4.181) 61.8 | 4 | 1.183 (0.975–1.435) 23.6 |
| Non-RFLP | 3 | 0.780 (0.525–1.158) 30.2 | 3 | 0.821 (0.645–1.045) 34.2 |
| Overall | 7 | 1.141 (0.734–1.773) 61.2 | 7 | 0.993 (0.800–1.232) 64.6 |
Abbreviations as in Table 4.
§
N:The number of studies included in subgroup.