Fig. 8.

Treatment with apelin-13 increases VEGF and apelin/APJ expression in bone marrow (BM)-derived PCs (BMPCs). A: results from Western blot analyses of VEGF expression in BMPCs. VEGF expression was significantly upregulated in BMPCs of apelin-13-treated ischemic mice compared with saline-treated mice at 24 h and 14 days post-MI. B and C: results from Western blot analyses of apelin (B) and APJ (C) expression in BMPCs. Apelin and APJ expression were upregulated in BMPCs of 14-day post-MI mice compared with sham control mice. Treatment with apelin-13 for 14 days further increased apelin and APJ expression in BMPCs of post-MI mice.