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In vivo transthoracic echocardiography measurements at 4 wk. A: LV end-diastolic diameter (LVEDD). B: LV end-systolic diameter (LVESDD). C: total wall thickness (TWT). D: LV ejection fraction (LVEF). Black bar, WT-saline mice; white bar, WT-aldosterone mice; gray bar, IFNγKO-saline mice; stippled bar, IFNγKO-aldosterone mice. Results are presented as means ± SE, n = 6–8/group. §P < 0.05 vs. WT-saline. ‡P < 0.001 vs. IFNγKO-saline. †P < 0.01 vs. IFNγKO-saline. NS, nonsignificant.
