Table 1. Summary of experimentally determined parameters.
2N2 | 2P | 4O | 4R | |||
Steady state levels | H.RNA | 781 | 250 | 71 | 137 | molecules*cell−1 |
L.RNA | 60611 | 41165 | 741 | 550 | ||
H | 4.7×106 | 2.5×106 | <0.1×106 | 2.3×106 | ||
L | 1.7×106 | 1.4×106 | 1.1×106 | 1.4×106 | ||
LL | 1.2×106 | 0.8×106 | 0.7×106 | 0.5×106 | ||
HL | 160×106 | 60×106 | 10×106 | >0.1×106 | ||
HH | <0.1×106 | <0.1×106 | <0.1×106 | <0.1×106 | ||
LHH | <0.1×106 | <0.1×106 | <0.1×106 | <0.1×106 | ||
LHHL | 12×106 | 2.6×106 | 1.4×106 | 2.3×106 | ||
secretion rates | qL | 37×106 | 1.6×106 | 0.4×106 | <0.1×106 | molecules *cell−1*h−1 |
qLL | 12×106 | 1.0×106 | 0.1×106 | <0.1×106 | ||
qmAb | 2.9×106 | 0.4×106 | 0.1×106 | <0.1×106 | ||
qHL | 11×106 | 0.7×106 | 0.1×106 | <0.1×106 | ||
rate constants | Growth | 0.020 | 0.025 | 0.036 | 0.025 | h−1 |
H.RNA decay | <0.025 | 0. 400 | 0.038 | 0.043 | ||
L.RNA decay | <0.025 | 0.109 | 0.026 | 0.026 |
H = heavy chain; L = light chain.