Table 1.

Metabolic characteristics of rats on a normal-salt diet, a low-salt diet, a normal-salt diet with candesartan, and a low-salt diet with candesartan on day 0 (baseline before any diet manipulations) and day 14 of treatment

	Normal Salt	Normal Salt+Candesarten	Low Salt	Low Salt+Candesarten
Baseline
Food intake, g/day	21.6 ± 0.5	21.9 ± 1.5	24.2 ± 0.4	22.0 ± 1.2
Water intake, g/day	33.0 ± 0.7	31.5 ± 0.7	28.3 ± 2.7	29.4 ± 2.5
UV, ml/day	15.8 ± 1.0	17.2 ± 1.1	15.2 ± 1.2	16.1 ± 0.6
UNaV, mmol/day	1.73 ± 0.04	1.88 ± 0.13	1.81 ± 0.12	1.84 ± 0.10
Ccreat, ml/min	1.02 ± 0.05	1.01 ± 0.09	1.03 ± 0.10	1.15 ± 0.12
Day 14
Food intake, g/day	20.8 ± 0.9	21.7 ± 0.6	16.4 ± 1.3*	14.5 ± 0.7*
Water intake, g/day	30.8 ± 2.2	32.0 ± 2.1	22.9 ± 1.7	31.7 ± 3.8
UV, ml/day	14.9 ± 1.8	15.3 ± 2.1	11.8 ± 1.7	17.5 ± 2.2
UNaV, mmol/day	1.67 ± 0.07	1.86 ± 0.25	0.005 ± 0.001*	0.028 ± 0.008*
Ccreat, ml/min	0.88 ± 0.06	1.17 ± 0.10†	0.71 ± 0.07	0.74 ± 0.05*

Values are means ± SE. UV, urine flow rate; UNaV, urinary sodium excretion; Ccreat, creatinine clearance.

^*P < 0.05 vs. a normal-salt diet.

^†P < 0.05 vs. the same salt diet alone; n = 5–6 rats/group.