Fig. 7.

Effect of renin inhibition on the progression of tubular lesions. Mice underwent kidney biopsy after receiving Doxy for 6 wk. Mice with renal lesion were administered either normal saline or aliskiren for either 4 wk (protocol D) or 8 wk (protocol E). A: representative microphotographs of renal cortical sections from the protocols D (4 wk) and E (8 wk) are shown. B: cumulative data showing percentage change in the size of microcysts in protocols D and E. *P < 0.01, compared with respective AD-VprD; **P < 0.001, compared with respective AD-VprE.