Skip to main content
. 2012 Jun 20;303(5):F711–F720. doi: 10.1152/ajprenal.00643.2011

Fig. 8.

Fig. 8.

Renin inhibition modulates biomarkers in Tg26 mice. A: aliskiren and hydralazine decrease blood pressure in Tg26 mice. Control and Tg26 were administered normal saline, aliskiren, or hydralazine for 4 wk. Blood pressure was recorded at the end of 1, 2, and 4 wk. *P < 0.001 vs. FVBN, week 1; **P < 0.001 vs. FVBN week 1. ***P < 0.001 vs. Tg, week 1. #P < 0.05 vs. FVBN, week 2; ##P < 0.001 vs. FVBN, week 2; ###P < 0.001 vs. Tg, week 2; ####P < 0.001 vs. Tg, week 2. †P < 0.001 vs. FVBN, week 4; ††P < 0.001 vs. FVBN, week 4; †††P < 0.001 vs. Tg, week 4; ††††P < 0.001 vs. Tg, week 4. B: urinary albumin-to-creatinine ratio in control receiving normal saline, Tg26 receiving normal saline (Tg + NS), and Tg 26 mice receiving aliskiren (Tg + Alis) at the end of 4 wk. *P < 0.001, compared with control; **P < 0.01, compared with Tg + NS. Urinary (U) albumin-to-creatinine ratio in control mice receiving normal saline, Tg26 receiving normal saline (Tg +S), and Tg 26 mice receiving hydralazine (Tg + hydra) at the end of 4 wk. *P < 0.01, compared with control.