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Chemical structure of the A1 adenosine receptor (AR) allosteric enhancer 2-amino-4,5-dimethyl-3-thienyl-[3-(trifluoromethyl)phenyl]methanone (PD-81723). Previous structure activity relationship studies have determined that chemicals with a 2-amino-3-benzoylthiophene core (outlined) are excellent A1AR allosteric enhancers.
