Fig. 3.

Differential cardiovascular effects of PD-81723 and CCPA. We compared the effects of a selective A₁AR allosteric enhancer (PD-81723) and a selective A₁AR agonist [2-chloro-N⁶-cyclopentyladenosine (CCPA)] on mouse heart rate (A) and systolic blood pressure (B). We measured systolic blood pressure as well as heart rate via an indwelling carotid artery catheter. PD-81723 (3 and 6 mg/kg ip) did not significantly change heart or systolic blood pressure in mice (n = 4). In contrast, CCPA (0.1 and 0.5mg/kg ip, n = 4) caused dose-dependent decreases in heart rate and systolic blood pressure in mice. Arrows indicate the time of drug injection. *P < 0.01 vs. baseline; #P < 0.01 vs. mice injected with 6 mg/kg PD-81723.