Fig. 4.

Renal protection with PD-81723 pretreatment. Plasma creatinine levels from A₁AR wild-type (WT) or A₁AR knockout (KO) mice subjected to sham surgery or to renal ischemia-reperfusion (I/R) are shown. A₁WT mice treated with 0.3–3 mg/kg PD-81723 15 min before renal ischemia were protected against renal I/R injury (n = 6 mice/group). PD-81723 significantly and dose dependently attenuated the increases in plasma creatinine after renal I/R in A₁WT mice. In contrast, PD-81723 failed to protect against renal injury in A₁KO mice. Values are means ± SE. *P < 0.05 vs. vehicle-treated A₁WT or A₁KO mice subjected to sham surgery; #P < 0.05 vs. vehicle-treated A₁WT mice subjected to renal I/R.