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PD-81723 induces renal SK1 in mice. A and B: representative images (top) and relative normalized band intensities (bottom) for kidney SK mRNA (by RT-PCR; A) and protein (by immunoblot analysis; B) expression after vehicle (1% DMSO) or PD-81723 (3 mg/kg ip) treatment (n = 4 per group). Kidneys were isolated 6 h after treatment. PD-81723 increased SK1 mRNA and protein expression in HK-2 cells but did not change SK2 expression. Values are means ± SE. *P < 0.05 vs. vehicle.
