Fig. 9.

Critical role for SK1 in PD-81723-mediated renal protection against I/R. Plasma creatinine levels in vehicle (1% DMSO)-treated or PD-81723 (3 mg/kg)-treated mice subjected to sham surgery (n = 4 mice/group) or to renal I/R (n = 6 mice/group) are shown. WT mice treated with a potent SK inhibitor (SKI-II; 50 mg/kg sc 15 min before ischemia) were not protected against renal I/R injury with PD-81723 treatment. Moreover, mice deficient in SK1 were not protected against renal I/R injury with PD-87123. In contrast, SK2-deficient mice were protected against renal I/R with PD-81723 treatment. Values are means ± SE. *P < 0.05 vs. vehicle-treated mice to subjected to renal I/R.