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. 2012 Jul 3;303(6):F873–F885. doi: 10.1152/ajprenal.00092.2012

Fig. 2.

Fig. 2.

HMGB1 in systemic arterial and renal venous blood following ischemic insult of increasing duration. Plasma HMGB1 was measured by Western blot analysis. Representative gels (A) and quantified data (B) of HMGB1 in venous blood leaving the kidney and arterial left ventricular blood after renal ischemia of 25, 40, and 55 min, with and without ethyl pyruvate (EP) treatment. HMGB1 increased in venous blood with increased duration of ischemia. EP treatment significantly attenuated the rise in venous blood HMGB1 during IRI. *P < 0.05 vs. control. †P < 0.05 vs. IRI 25 min. ‡P < 0.05 vs. arterial. #P < 0.05 vs. EP; n = 6.