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Increasing cAMP increases pendrin abundance in the CCD and CNT. CCDs and CNTs were cultured overnight in the presence of 1 mM 8-bromo (Br)-cAMP or vehicle. For each segment, we compared the effect of cAMP or vehicle on pendrin immunolabel in tubules taken from the same mouse. Top: representative tubules labeled for pendrin taken following culture with 8-Br-cAMP or vehicle. Bottom: effect of cAMP on the means ± SE of pendrin label intensity in each segment. *P < 0.05.
