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. 2012 Oct 10;7(10):e47089. doi: 10.1371/journal.pone.0047089

Figure 2. Plasma adrenocorticotropic hormone (ACTH) (A) and corticosterone (B) concentrations 60 min after saline (Sal) or naloxone (Nx) administration to placebo or morphine dependent rats pretreated with Tween 80 (Tw) or CP-154,526 (20 mg/kg, i.p., CP).

Figure 2

Data are the mean±SEM (n = 6–9). ***p<0.001 versus the morphine dependent group receiving saline instead of naloxone; +++p<0.001 versus the placebo group injected with Tw+Nx; &&p<0.01 versus morphine+Tw+Nx; ###p<0.001 versus morphine+CP+Sal; $$$p<0.001 versus placebo+CP+Nx.