Fig. 8.

Effects of AMPK activators and inhibitor on zymogen activation in pancreatic acini. Cerulein-stimulated trypsin (A) and chymotrypsin (B) activity are significantly reduced by pretreatment with AICAR (2 mM) or metformin (12.5 mM). Conversely, compound C (20 μM) significantly enhances trypsin activity. C: cerulein-stimulated amylase secretion (CER, solid bars) is significantly reduced by pretreatment with metformin (12.5 mM) but not AICAR (2 mM) and compound C (20 μM). *P < 0.05 vs. CTL; **P < 0.05 vs. CER; n ≥ 3.