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. 2012 Oct 10;7(10):e47325. doi: 10.1371/journal.pone.0047325

Figure 2. Expression of p53 target genes in human breast tumors.

Figure 2

Boxplots of the intratumoral p53, MDM2, p21, BAX and PERP mRNA levels of breast cancer patients, normalized to β-actin. A, Results for unselected patients with genotype Arg/Arg (n = 36) and Pro-allele carriers (n = 37). Median mRNA expression levels of Arg/Arg patients were set to 1, and median levels of Pro-allele carriers (Arg/Pro, Pro/Pro) are expressed relative to the levels of Arg/Arg patients. B, Results for patients with TP53 wildtype (wt) tumors with genotype Arg/Arg (n = 24) and for Pro-allele carriers (n = 25), and patients with TP53 mutated (mut) tumors with genotype Arg/Arg (n = 12) and for Pro-allele carriers (n = 12). Median mRNA expression levels of Arg/Arg patients with wildtype p53 were set to unity, and the levels of Arg/Arg patients with mutant p53, and of Pro-carriers with wildtype or mutant p53 are expressed relative to those. **indicates p-values <0.01; *indicates p-values <0.05 (Wilcoxon-Mann-Whitney U-Test).