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. 2012 Oct 10;7(10):e47574. doi: 10.1371/journal.pone.0047574

Figure 1. Experimental design.

Figure 1

In the main experiment (A), dystonic patients received premotor cTBS600 on five consecutive days. Rest motor threshold (RMT) was assessed at the beginning of the experiment on day 1 and day 5. The amplitude of MEPs, writing tests and SICI/ICF were recorded before and after premotor cTBS600 on day 1 and 5. Motor plasticity assessed by cTBS300 given to M1 was measured more than one week before or one month after the 5-day premotor cTBS600 and 2 hours after premotor cTBS600 on day 5. In a control study (B), only a single session of premotor cTBS600 was given to dystonic and healthy subjects. The amplitude of MEPs was recorded before and after premotor cTBS600. Motor plasticity was assessed more than one week before or one month after premotor cTBS600 and 2 hours after premotor cTBS600. Motor plasticity was assessed by the change in the size of MEP that is induced by cTBS300 given to M1 (C).