Table 3. Clinical, biochemical and histopathological patient characteristics.
| qRTPCR biopsy samples | ||||
| Steatohepatitis (n = 11) | Steatosis (n = 13) | Controls (n = 5) | p-value | |
| sex (m∶f) | 6∶05 | 9∶04 | 4∶01 | |
| age (y) | 54 (34–69) | 45 (25–62) | 43 (28–50) | 0.07 |
| BMI (kg/m2) | 28.8 (25.2–31.6) | 28.3 (22.8–35.5) | 26.7 (24.3–27.7) | 0.19 |
| ALT (IU/l) | 83 (43–154) | 75 (21–253) | 66 (39–130) | 0.59 |
| AST (IU/l) | 68 (35–520) | 42 (19–137) | 41 (33–65) | 0.07 |
| GGT (IU/l) | 426 (98–2195) | 171 (17–536) | 40 (27–69) | 0.00 a, c |
| AP (IU/l) | 118 (76–267) | 87 (37–224) | 55 (38–69) | 0.01 b |
| Bilirubin (mg/dl) | 1 (0.4–1.7) | 0.68 (0.3–3.6) | 0.46 (0.4–1.5) | 0.27 |
| Cholesterol (mg/dl) | 258 (131–326) | 206 (146–259) | 142 (125–177) | 0.04 b,c |
| Triglycerides (mg/dl) | 185 (127–488) | 161 (51–324) | 43 (20–56) | 0.01 b,c |
| Diabetes II (Y/N) | 4/7 | 3/8 | 0/5 | |
| Hyperlipidaemia (Y/N) | 3/8 | 3/8 | 0/5 | |
| Hypertension (Y/N) | 5/6 | 4/7 | 0/5 | |
| Steatosis grade (0∶1∶2∶3) | 0∶3∶3∶4 | 0∶5∶3∶3 | 4∶1∶0∶0 | |
| Lobular inflammation (0∶A1∶A2∶A3) | 0∶2∶5∶3 | 1∶5∶5∶0 | n/a | |
| Ballooning (0∶1∶2) | 0∶9∶1 | 11∶0∶0 | 5∶0∶0 | |
| Matteoni (points) | 4 (2–4) | 2 (1–2) | n/a | |
| Fibrosis (0∶F1∶F2∶F3∶F4) | 0∶5∶1∶0∶4 | 7∶2∶1∶0∶1 | n/a | |
| Apoptosis (0∶1∶2) | 4∶6∶0 | 8∶3∶0 | n/a | |
| Alcoholic/non-alcoholic | 3∶8 | 0∶13 | n/a | |
Samples from the Biopsy cohort used for the validation by qRT-PCR (p-value: a. steatohepatitis vs. steatosis, b. steatohepatitis vs. control, c. steatosis vs. control).