Table 1. Effects of 1.4 mM sodium salicylate (NaSal) on action potential properties (n = 10).
Measurements | Before NaSal perfusion | After NaSal perfusion | ||||
Threshold (mV)1 | −31.3 | ± | 1.4 | −29.3 | ± | 1.6* |
Amplitude (mV)2 | 68.0 | ± | 2.7 | 63.4 | ± | 2.8** |
Rise slope (mV/ms) | 83.4 | ± | 11.9 | 72.4 | ± | 11.9* |
Decay slope (mV/ms) | −32.6 | ± | 3.1 | −29.0 | ± | 2.7** |
Half-width (ms) | 1.5 | ± | 0.1 | 1.6 | ± | 0.1* |
Threshold current (pA)3 | 44.5 | ± | 6.7 | 77.5 | ± | 11.8*** |
All data are expressed as means ± SEM. *, ** and *** indicate P<0.05, P<0.01 and P<0.001, respectively (paired Student's t-test).
The action potential threshold was defined as the membrane potential at which the potential of the membrane began to rise rapidly and the neuron generated only one or two spikes.
The action potential amplitude was calculated by subtracting the threshold from the peak value of the action potential.
The threshold current was defined as the minimum current that is required to elicit one or two spikes.