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. 2012 Oct 10;7(10):e46781. doi: 10.1371/journal.pone.0046781

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© 2012 Wang et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) ACh-induced relaxation in untreated ZDF rats was significantly reduced compared to that in lean controls. Relaxations were significantly increased in ZDF rats supplemented with NWT-03, but not in those treated with VIL. Pre-incubation with the COX-inhibitor indomethacin (INDO) profoundly improved relaxation to ACh in untreated ZDF rats (not shown in panel A; see lean vs. ZDF in panel B). The area under the curve (AUC) for ACh-induced relaxation in the absence and presence of INDO was determined for each group and used to calculate the percentage improvement. Data are means ± SEMs; significant differences are as indicated (repeated measures ANOVA). (B) Acute COX inhibition improved ACh-induced relaxation to a significantly smaller extent in ZDF rats supplemented with NWT-03, indicating a diminished suppression of relaxation by contractile PGs in the latter rats. Data are means ± SEMs (***p<0.001 vs. lean; #p<0.05 vs. ZDF).