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. 2012 Jul 18;17(6):779–790. doi: 10.1007/s12192-012-0350-6

Fig. 6.

Fig. 6

Proposed relationships between the loss of heterozygosity (LOH) with the expression of Hsp27. The molecular pathways linking the LOH with the expression of Hsp27 are unknown. However, we observe that the final result leading to an increase or decrease in Hsp27 is then reflected in a good or bad prognosis. Hsp27 is emerging as a sensor of genetic imbalances (haploinsufficiency) in the cell