Table 2.
Clinical and serological features of 13 autoimmune hepatitis patients with centrilobular necrosis
| Case | Age (yr)/sex | ALT (IU/L) | ALP (IU/L) | IgG (mg/dL) | ANA (titer) | ASMA (titer) |
AIH score |
HLA |
Histology |
|||||
| (O) | (S) | DR4 | (I) | (L) | (R) | (E) | (F) | |||||||
| 1 | 56/F | 831 | 357 | 3330 | 5120 | 40 | 20 | 8 | DR4 | + | + | + | + | 3 |
| 2 | 68/F | 1230 | 479 | 3215 | 640 | Neg | 11 | 7 | - | + | + | + | - | 3 |
| 3 | 45/F | 3250 | 423 | 1800 | 160 | Neg | 14 | 6 | DR4 | + | + | - | - | 2 |
| 4 | 49/M | 713 | 528 | 2300 | 640 | 40 | 15 | 7 | DR4 | + | + | + | - | 1 |
| 5 | 23/F | 789 | 596 | 3913 | 160 | 640 | 17 | 7 | DR4 | + | + | - | - | 1 |
| 6 | 42/M | 1499 | 972 | 1150 | Neg | Neg | 9 | 3 | DR4 | - | + | - | - | 1 |
| 7 | 57/F | 471 | 223 | 2266 | Neg | 20 | 6 | 3 | DR4 | + | + | - | - | 1 |
| 8 | 80/F | 499 | 410 | 1410 | 40 | Neg | 11 | 4 | - | + | + | - | - | 1 |
| 9 | 52/F | 416 | 458 | 1280 | Neg | 160 | 11 | 5 | - | - | + | - | - | 1 |
| 10 | 44/F | 1067 | 377 | 1370 | Neg | Neg | 6 | 3 | DR4 | - | + | + | - | 1 |
| 11 | 44/F | 418 | 273 | 3503 | 2560 | Neg | 14 | 7 | - | + | + | - | - | 2 |
| 12 | 35/F | 383 | 335 | 3086 | 160 | 80 | 17 | 7 | ND | + | + | - | - | 1 |
| 13 | 69/F | 228 | 999 | 1286 | 160 | Neg | 13 | 5 | - | + | + | - | - | 2 |
Abbreviations (normal values): ALT: Alanine aminotransferase (8-42 IU/L); ALP: Alkaline phosphatase (115-359 IU/L); IgG: Immunoglobulin G (870-1700 mg/dL); ANA: Antinuclear antibody (< 40 ×); ASMA: Anti-smooth muscle antibody (negative); O: Original system; S: Simplified system; I: Interface hepatitis; L: Lymphocytic/lymphoplasmocytic infiltrates in portal tracts; R: Rosette formation; E: Emperipolesis; F: Fibrosis; Neg: Negative; ND: Not detected; F: Female; M: Male; AIH: Autoimmune hepatitis.