Fig. 1.

(A) Flinching behavior observed after the intraplantar injection of 1% formalin in the right hind paw of Wistar rats in absence (black symbols) of in presence (open symbols) of 100 mg/kg oral curcumin. (B) Area under the number of flinches-against-time curve of the second phase of the formalin test observed in Wistar rats in presence of increasing doses of oral curcumin. (C) Percent of antinociception observed in the second phase of the formalin test in presence of increasing doses of oral curcumin. Data are presented as mean ± SEM of six animals. ^*Denotes a statistically significant difference (P < 0.05) with respect to the effect observed in absence of curcumin.