Fig. 2.

Antinociceptive effect of 100 mg/kg oral curcumin in the second phase of the formalin test in Wistar rats submitted to local pretreatment with increasing doses of L-NAME (A), ODQ (B) and glibenclamide (C). Data are presented as mean ± SEM of six animals. ^*Denotes a statistically significant difference (P < 0.05) with respect to the effect observed in absence of glibenclamide.